In what might be the toughest region, the Southwest is set and features Kansas, Notre Dame, Purdue and Louisville as the top four seeds.
Vanderbilt, Georgetown, Richmond and USC (should they make the main draw), who are as erratic as their coach, will provide for some interesting matchups as well.
Within this region there are some outstanding talents, some of whom are less than household names in college basketball. But each is as important to his team as the next.
Here is a list of players to watch.