Duke has only played Louisville once since 1986 and can avenge its most memorable loss 27 years ago to the Cardinals in Elite Eight action Sunday.
Mike Krzyzewski and his Blue Devils lost the NCAA championship game to Denny Crum, Pervis Ellison and the Cardinals way back in 1986. And they are underdogs this time, as most sportsbooks tracked by OddsShark.com pegged Louisville at -3.5 late Saturday.
Coach Crum and "Never-Nervous" Pervis are gone from the college basketball scene, but Coach K and his Dukies remain a perennial contender. They now sit one win away from yet another trip to the Final Four.
But it won't come easy, going up against the champions of the Big East, a team that went to the Final Four last year and looms as the favorite to win this tournament next weekend – the latest version of the Cards from the 'Ville.
In a match-up that would make for a great national championship game, these teams clash in the Midwest Regional final Sunday afternoon at Lucas Oil Stadium in Indianapolis (5 pm ET, CBS).
Duke has been an underdog just five times all season, and they are 2-3 ATS, according to the college basketball database. Louisville meanwhile has played OVER the total seven straight times as a favorite.
This is a very rare season for the Blue Devils (30-5 SU, 19-16 ATS), who didn't win either the ACC regular-season title or the conference tournament. But they were still good enough to earn a No. 2 seed for the Big Dance.
The Dukies then began this NCAA tournament with a 73-61 win over Albany and a 66-50 decision over Creighton.
Then Friday night, led by 29 points from Seth Curry, Duke out-classed Michigan State 71-61.
In the other corner, Louisville (32-5 SU, 22-15 ATS) finished in a tie for first place in the Big East this season, then won the conference tournament for the second straight season.
That was enough to garner the Cardinals a No. 1 seed for this NCAA tournament.
Louisville then began the Dance with easy wins over North Carolina A&T and Colorado State, then Friday night took care of business with a 77-69 victory over Oregon.
These two teams hadn't met since their 1986 NCAA championship bout until last November, when the Dukies defeated the Cardinals 76-71 in the championship game of the Battle 4 Atlantis tournament in the Bahamas.
That game was tied at 61 with five minutes to go, until Curry hit a 3-pointer to give Duke the lead for good.