Picking the winners in the NCAA tournament is a science of its own, but things get even more complicated when the point spread is thrown into the mix. Even a No. 1 vs. No. 16 seeding matchup can become a challenge to pick when the favorite has to cover a ridiculous spread.
By the same token, an underdog who might or might not pull of the upset becomes a great option with a few points in their favor. Picking Virginia Commonwealth to knock off a tough Wichita State team is one thing, but picking the Rams +6 points is a much surer proposition.
Herein, a look at the best picks against the spread for the first two days of March Madness action.
All point spreads from docsports.com.