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Alex Smith and the Niners are 6-0-1 ATS and 3-0 in the east. Change is inevitable.
When you hit rock bottom, there's only one place to go, and that's up.
This week it's the Redskins, who return home off a shutout at Buffalo and take on the surprising 49ers.
But the most surprising thing about Jim Harbaugh's team may not be their 6-1 record.
Teams from the west coast traveling east and playing a 1:00 game in the eastern time zone have won only 35 percent of their games in recent years (a record of 28-52), but don't tell that to Alex Smith and Jim Harbaugh.
San Francisco already won at Philadelphia and Cincinnati in the 1:00 eastern time slot and won in Detroit in the 1:00 time slot as well.
Even more impressively, they were underdogs in all three games.
This time they are favored.
One of the "factors" in this game is to realize is the 49ers are (+10) in turnover margin while the Redskins are (-6), which accounts for a 16-possession difference. That's significant for not even being halfway through the season.
NFL teams rarely get shutout twice in a row, so expect the Redskins will get some points in this game.
Unlike teams such as the Colts, who were seemingly set up to lose games this season due to very poor management at the upper levels, at least the Redskins are trying to improve. The team recently acquired running back Tashard Choice, who was released from the Cowboys last week, to step up the running game. His status is listed as "out" for the game against San Francisco, but keep that in mind when the Redskins play Dallas in two weeks.
"The best is yet to come" said Choice on his Twitter page.
For this game, the Redskins will have to milk every piece of their home-field advantage. Although cross-country travel often doesn't affect the best and most mature teams in the NFL, it could be a factor here.
The 49ers had to go to Philadelphia, then back home to play Tampa Bay. Then they had to travel to Detroit before coming back home to play Cleveland. Now they must go across the country again to play the Redskins in an early game, and history indicates a possible jet lag for Harbaugh's crew.
Of the four teams on the west coast, 17 times over the last decade they have played at least four games in the eastern time zone in a single season.
Only two times did these teams win at least four of those games, and one of them was San Francisco in 2001 as the 49ers won a pair of those games by a combined five points.
So, just once out of 17 times over the last 10 years did west coast teams win four east coast games by more than a field goal.
Even the Super Bowl teams (Seattle from 2005 and Oakland from 2001) failed at this task.
Already having a trio of wins over Detroit, Cincinnati and Philadelphia in the 1:00 eastern time slot, the third time might not be a charm.
Yet to lose a game against the spread, this is a fine time to go the other way for a game with San Francisco.
Don't expect the Niners to pull off the east coast treat four times in one, make that one-half, of a season.
Take Washington to cover 4 points