San Francisco 49ers Week 5: Stat Predictions for Key Players vs. Buffalo Bills

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San Francisco 49ers Week 5: Stat Predictions for Key Players vs. Buffalo Bills
Jeff Zelevansky/Getty Images

After posting their most dominating victory of the season against the New York Jets, the San Francisco 49ers return home to face the Buffalo Bills, a team with a much more potent offense.

In Week 1, the Jets beat the Bills 48-28, and using point-differential logic, the 49ers should win by 54 points on Sunday.

Jokes aside, the 49ers are heavy favorites in this one and for good reason.

The Bills just allowed 52 points to the Patriots, including 45 in the second half.

Will Alex Smith and company take advantage of Buffalo's struggling defense?

Let's look at some stat predictions for Sunday's matchup.

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