The Bills defense is likely to spot the 49ers an early lead. It will be important that Buffalo head coach Chan Gailey doesn't give up on the run game, which features two explosive backs in C.J. Spiller and Fred Jackson, both of whom, according to BuffaloBills.com, are recovering nicely from their injuries.
At some point, I suspect the Bills will fall behind by two scores and become one-dimensional. This will give Aldon Smith, Ahmad Brooks and the Niners' defensive line plenty of opportunities to pressure Ryan Fitzpatrick.
San Francisco's sack total may not be all that impressive, but as long as the 49ers defense is getting pressure on Fitzpatrick, it should force multiple turnovers.
Justin Smith: four tackles
Ray McDonald: three tackles
Aldon Smith: three tackles, 1.0 sacks
Ahmad Brooks: two tackles, 1.0 sacks
Patrick Willis: eight tackles
NaVorro Bowman: nine tackles
Carlos Rogers: three tackles, interception
Tarell Brown: two tackles, interception
Donte Whitner: six tackles
Dashon Goldson: three tackles, interception