Both teams will potentially be left without their starting running backs which can make both teams one-dimensional.
St. Louis is clearly coming into the game with momentum.
But the magic of the NFL is that any team can win, and the Bears are capable of going 2-1 as long as the right players take advantage of their matchups.
Charles Tillman may have his hands full going up against the St. Louis Rams' receivers.
Danny Amendola had a record game last week against the Washington Redskins as he exploded for 160 yards and a touchdown with 15 receptions, according to ESPN.com.
Of course, such an astonishing performance isn't usually repeated in the following game, but the threat of a pass-happy Sam Bradford in combination with Amendola's recent success is a call to action for Charles Tillman.
Expect Tillman to step up and defend the young Rams receivers to prevent a stat line of Amendola's magnitude from happening at Soldier Field.
The Rams will most likely be without starting running back Steven Jackson, who is nursing a groin injury. If Isaiah Pead or any of the other Rams backups are unable to get the running game going, the team's offense will be one-dimensional, which should translate into an easier time for Tillman.
His inconsistent performances on a weekly basis have plagued the team since he was traded from the Denver Broncos.
There may be an opportunity to shine against a Rams passing defense that has allowed 275.1 yards per game.
Cutler has averaged 229.5 yards in the past two games so he may have the opportunity to sling the ball down the field more than usual, which should give the opportunity for Cutler to shift his touchdown-to-interception ratio in the right direction.
As bad as Jay Cutler has been these past two weeks, throwing five interceptions with only three touchdowns, his offensive line deserves most, if not all, of the blame.
Cutler was sacked only once in Week 1 against the Indianapolis Colts, but the offensive line's performance in Week 2 against the Green Bay Packers was horrendous.
The Packers defense was able to sack Cutler a staggering seven times.
These sorts of defensive statistics don't happen very often, and they probably won't happen to the Bears this season if the offensive line has learned its lesson.
Look for the offensive line to improve in Week 3, especially considering that the Bears offensive line has already allowed Matt Forte to be dinged up last week. They can't afford to slip up and allow the same to happen to backup Michael Bush.
Running back Matt Forte is presumably out after suffering an ankle sprain in Week 2 against the Green Bay Packers.
Although his injury is a setback to the Bears, they do have backup Michael Bush.
Mark Potash of the Chicago Sun-Times reports that head coach Lovie Smith is comfortable with the fact that Bush is starting in place of the injured Matt forte.
McFadden played only seven games due to injury last season, which gave Bush the opportunity to rush for 977 yards and score seven touchdowns.
Bush has the opportunity to continue that type of production against the Rams, who have a below-average rushing defense. St. Louis has the 21st-best rushing defense in the league allowing 129.5 yards per game to opposing backs, according to NFL.com.
Look for Bush to take advantage of the run-of-the-mill defense, especially considering Jay Cutler’s lackluster performances in the past two games.