Collins is one of New York's defensive leaders, and the team can ill afford to lose him for significant time after he reached the Pro Bowl in 2016 with five interceptions and 125 combined tackles.
The Alabama product entered the day leading the team with 102 tackles this year, with Damon Harrison a distant second at 64.
Collins was a consensus All-American in 2014 at Alabama and immediately adapted to the NFL game with his ability to provide run support and dish out big hits when players crossed over the middle. He appeared in all 16 contests as a rookie and tallied 112 combined tackles and an interception.
Others must now fill the void in the secondary alongside Darian Thompson until Collins returns to the field.
Look for Andrew Adams to slide into Collins' role for the time being. While Adams and Thompson can keep the Giants afloat, it is unrealistic to expect them to replicate Collins' production. Unless he quickly returns to full health, it is difficult to envision New York's defense slowing down the offenses it faces the remainder of the year.