Darius Butler vs. Brandin Cooks
The entire secondary will be put under the microscope against Drew Brees, but the matchup to watch throughout will be between Darius Butler and Brandin Cooks in the slot.
When Vontae Davis and Greg Toler are both healthy and on the field, Butler tends to thrive as a nickel corner, shutting down slot receivers. Butler's speed will be put to the test on Saturday, however, as he goes against promising rookie Brandin Cooks, who has already caught six passes for 71 yards and a touchdown this preseason.
Cooks might end up being one of the deadliest slot receivers in the league in terms of speed, so this will be a great test for Butler to see if he can keep up.
Andrew Luck vs. Saints Secondary
Last season, the Saints allowed just 194.1 passing yards per game, the second-fewest in the league. Now they've added even more talent in the secondary, so Luck may have a tougher time finding his receivers than he did against the Giants.
The Saints were able to add Champ Bailey at cornerback while pairing promising sophomore safety Kenny Vaccaro with Jairus Byrd in free agency. With talent and some depth in the defensive backfield, the Saints look set to shut down opposing quarterbacks once again.
Luck has already developed great timing with most of his receivers, so he'll try to get the offense moving, but this Saints defense has changed a lot since giving up 7,042 total yards in 2012.
Colts Run Defense vs. Mark Ingram
After completely shutting down the run against the Giants, the Colts are feeling quite confident defensively, but they're going to have to make sure to not sleep on Mark Ingram, who is looking to finally have the breakout season he's been waiting for in the NFL.
In two games this preseason, Ingram has looked quite promising. Along with rushing for 83 yards and a touchdown on only eight carries in their first game, he also had a 23-yard touchdown reception this past week against the Tennessee Titans.
The front seven for the Colts has some interesting new pieces this season, and they look to be working so far. The Saints aren't the best running team, but that's because they don't have to rely on the run with Brees under center. Ingram is hoping to prove himself, so the Colts will have a potentially touch matchup in the trenches.
Colts' X-Factor of the Week: Bjoern Werner
As I said earlier, Werner is going to have to be a big part of the pass rush for the first quarter of the season, and this is a reasonable test for the former Florida State defensive end with Mathis not playing on Saturday.
Werner will be going up against second-year offensive tackle Terron Armstead, who the Saints have very high hopes for after he was inactive for 10 games in his rookie season. He didn't shine when on the field last year, but he showed a ton of potential. If Werner can get past Armstead, it will say a lot about his progress this offseason.
When watching Werner Saturday, don't look for how many times he hits Brees, but keep an eye on whether or not he's at least able to put some pressure on the veteran quarterback.