An incredible start from Lewis Hamilton took him well clear of the field by the end of the first lap and two seconds ahead by the end of the second.
In an exciting opening, Kimi Raikkonen noted right-rear tyre problems after a coming together with Kevin Magnussen, per AutoSport.com's Ben Anderson, and he was already in the pits by the third lap.
Vettel made use of the DRS to overtake team-mate Ricciardo by the fourth lap, and he started to make in-roads on Rosberg.
A crash on Lap 5 between Pastor Maldonado and Jules Bianchi saw Bianchi receive a five-second penalty and the former was forced to retire just two laps later because of engine difficulties.
Hamilton's first pit stop on Lap 16 briefly saw Nico Hulkenberg take the lead for half a lap with Jean-Eric Vergne retiring shortly afterward after complaining of a lack of power throughout the race, according to The Hindu.
Vettel continued to set his best laps through the middle part of the race, but he was never quite close enough to trouble Rosberg.
Ricciardo suffered a disastrous pit stop on Lap 41, meaning Red Bull will now be investigated for an unsafe release.
Some late heroics between Hulkenberg and Fernando Alonso, as each passed the other twice, got the crowd on their feet.
There was simply no stopping Hamilton, however, who finished a majestic 17 seconds ahead of the field.
Here's the story of the race including full results, updated standings and post-race reaction.