Denver has experienced some injuries to their offensive line this season with Dan Koppen going down in training camp, Ryan Clady being lost for the season and Orlando Franklin missing the game against Indianapolis.
But whether it is Chris Clark, Louis Vasquez or Manny Ramirez, the players they do have on the offensive line can't let Peyton Manning get pressured the way he was on Sunday night.
Robert Mathis, who leads the NFL in sacks, changed the game with his hit on Manning near the Denver end zone.
The play led to a safety but it also appeared Manning became a different player. The ball wasn't coming out of his hand the way it usually does and many of his passes wobbled through the air.
Manning was also way off target on any of his throws late in the game and would have had more than the 20 incompletions he threw if not for some circus catches by Wes Welker.
Indianapolis has provided a blueprint for the rest of the league on how to beat the Broncos. The offensive line will have to find a way to keep the elite pass-rushers away from their franchise quarterback.