San Francisco 49ers vs. Green Bay Packers: Betting Odds, Preview and Pick ColumnistSeptember 8, 2012

GREEN BAY, WI - AUGUST 30:  Aaron Rodgers #12 of the Green Bay Packers participates in warm-ups before a preseason game against the Kansas City Chiefs at Lambeau Field on August 30, 2012 in Green Bay, Wisconsin. The Packers defeated the Chiefs 24-3.  (Photo by Jonathan Daniel/Getty Images)
Jonathan Daniel/Getty Images

Last year’s two top seeds in the NFC clash in a potential playoff preview when the Green Bay Packers host the San Francisco 49ers at Lambeau Field.

And if past performance dictates future events, the Packers will cover the spread here in Week 1 as a five-point home favorite at almost every sportsbook.

*Editor Note: For matchup details on the Divisional Playoff odds between the 49ers and Packers.

"The Packers have been one of the league's best teams as a home favorite and they have won and covered five straight season openers," explained Jack Randall, a handicapping analyst at

Indeed, the chart shows Green Bay at 24-12-2 ATS as home chalk since the 2006 season. But the 49ers have also been a good Week 1 bet at 6-2-1 ATS in the past nine seasons.

In 2011, it was everything but the finish for the Green Bay Packers. Green Bay followed up its 2010 Super Bowl with a magnificent regular season in 2011, flirting with perfection with a 15-1 straight-up record with an 11-5 ATS record as well.

Expected to defend their Super Bowl title come playoff time, the Packers fell to the New York Giants in their first game of the postseason. With Aaron Rodgers back at the helm of what should once again be one of the NFL’s elite teams, the only question seems to be how far will the Packers go this season?

The San Francisco 49ers and new head coach Jim Harbaugh were a perfect fit. For years, San Francisco has had the talent but underachieved. But in 2011, under Harbaugh, San Francisco played to its potential to the tune of a 13-3 straight-up regular season with an 11-4-1 ATS record.

Bringing in Randy Moss and Mario Manningham in the receiving corps and running backs Brandon Jacobs and LaMichael James to back up Frank Gore, San Francisco could be even better in 2012. 

Both of these teams are considerable favorites to win their respective divisions, and both are also receiving plenty of Super Bowl hype. But which team will take Game 1 of the regular season? The game being played at Lambeau Field helps Green Bay.

The Packers, runaway favorites to capture the NFC North again in 2012, have also enjoyed success against San Francisco over the years; since 1998, Green Bay is 9-1 SU and 7-1-2 ATS against San Francisco.

But that wasn’t against Harbaugh’s unit, which is much more sound defensively. Green Bay might come out on top, but in what should be a dogfight to the end, we’ll take the points on the 49ers.

The total has also been climbing, to 47 at one shop, according to the Packers-49ers matchup report from

PICK: San Francisco +5 (courtesy of