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It's not easy to pick against them, but the Washington Redskins may struggle to overcome the Buffalo Bills in Toronto, thanks to too many injuries and issues on offense.
The Redskins' offensive line continues to struggle and could find it difficult to hold up against hulking defensive tackle Marcell Dareus.
The season-ending injury to Tim Hightower creates an opportunity for Ryan Torain, and he must deliver a big day on the ground to take the pressure off uncertain quarterback John Beck.
If the Redskins continue to take so many chances defensively, then explosive young Bills wideout Stevie Johnson has the ability to punish them.
There is also a risk that talismanic inside linebacker London Fletcher might miss the game. Without Fletcher, the Redskins' chances of stopping tough Buffalo running back Fred Jackson are severely diminished.
The game may only be decided by a field goal or less, but the Redskins are starting to look like a team headed for troubled times.