Wanyama was most recently sent off on Saturday in the 54th minute of the Saints' 1-0 win over West Ham United. Since it was his third red card of the 2015/16 season, he incurred the mandatory suspension.
The Kenya international didn't make a lot of contact with West Ham midfielder Dimitri Payet, but the intent was more than enough to warrant an immediate ejection. Southampton manager Ronald Koeman was critical of the tackle after the match, per Sky Sports Football:
"When I saw it in real time it looked like a red card," said West Ham manager Slaven Bilic, per the Guardian's Alan Smith. "I don't say that because I am the West Ham manager—it is a red card. He was lucky because if you get him then you are in big trouble. For me there is no place in football for those kind of tackles and they should be punished."
Wanyama will now be eligible to return March 19 against Liverpool. His absence certainly won't help Southampton climb into a European place, with the Saints 10 points back of Manchester City for fourth and four points behind fifth-place Manchester United.
Oriol Romeu is the likeliest replacement for Wanyama in the Southampton midfield. The 24-year-old Spaniard has looked good in his limited time on the pitch, and Wanyama's suspension could prove to have a silver lining should Romeu use the chance to prove why he's regularly deserving of a starting place.