Point spread: 49ers opened as 11.5-point favorites; the total was 42. (Line updates and matchup report)
Odds Shark computer prediction: 27.2-21.7 49ers
Why the Rams can cover the spread
St. Louis has won two in a row and four of its last seven games, while it has covered three of its last four. The Rams, undoubtedly under the guidance of coach Jeff Fisher, have outscored their opponents by an average of 38-15.5 in those four wins, including a 38-8 road win over the Colts.
They also bring a 5-2 ATS streak in games played at San Francisco.
Why the 49ers can cover the spread
After two trying road trips—to New Orleans and Washington D.C.—the past two weeks, the Niners will be glad to be at home over the next two weeks and three of the next four. San Francisco can't afford any letdowns with the Arizona Cardinals in the mix for a wild-card berth.
The Rams are the play here, as they're exuding confidence right now and will come in fired up knowing they have a chance to gain some ground on San Francisco in the NFC West. Plus, the Niners could get caught looking ahead to the Seahawks next week.
- St. Louis is 5-2 ATS in its last seven games when playing San Francisco
San Francisco is 15-8 ATS in its last 23 games at home
Rams have been shut out two of past four trips here