According to Scott French of MLSSoccer.com, the midfielder has been ruled out of his club's upcoming CONCACAF Champions League match against Isidro Metapan.
Donovan injured his ankle in Saturday's match against D.C. United and was removed at halftime. He had this to say about the incident:
It was my fault. I gave away a bad ball in midfield and then won it back, but Silva and I got tangled up, he fell on my ankle and it rolled. I couldn't run anymore. I was trying to run and I couldn't run. At that point, you're doing yourself more damage and the team damage.
The veteran has only made 17 starts for the Galaxy this season out of a possible 28, but he is second on the team with eight goals and eight assists. He trails only Robbie Keane in each category.
Still, the club has certainly suffered without him. They stand in fourth place in the Western Conference with only six matches remaining in the regular season. Clint Dempsey's Seattle Sounders are currently in first place.
It will take a strong finishing effort to win a third MLS Cup in a row.
Additionally, the club hopes to contend for a CONCACAF Champions League title, something that will be difficult to claim without its star player.
As far as the United States national team goes, the Yanks can afford to rest their star player after clinching a bid to the 2014 World Cup with a win over Mexico.
Still, the squad cannot afford many more injuries after losing Michael Bradley to an ankle injury earlier in the month.
Both teams certainly hope that Donovan's injury is not too serious.
Follow Rob Goldberg on Twitter for the latest breaking news and analysis.