NFL Week 1 Picks: New England Patriots vs. Buffalo Bills

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NFL Week 1 Picks: New England Patriots vs. Buffalo Bills
Jared Wickerham/Getty Images

The New England Patriots are 8-1 against the spread in their last nine road games against the Buffalo Bills, which is important to consider when making your Week 1 NFL picks, with the teams scheduled to meet on Sunday, Sept. 8 at Ralph Wilson Stadium.

Sports bettors will find that the Patriots are 6.5-point favorites in the pro football odds (courtesy of SBR Forum), while the total sits at 53 in the market.

Let's take a closer look at this AFC East matchup from a betting perspective, while offering up a prediction on the total along the way. 

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