LeBron James has left the Miami Heat's regular-season opener versus the Boston Celtics multiple times with cramping issues.

UPDATE: Tuesday, October 30 at 10:27 p.m. ET by Ian Hanford

According to the Heat's Twitter feed, James may, or may not, return:

#HEATgame: @kingjames has leg cramps, his return is questionable.

— Miami HEAT (@MiamiHEAT) October 31, 2012

---End of Update---

James limped off the court in the NBA season opener with an apparent ankle injury. The game is a rematch of last season's Eastern Conference Finals and his Miami Heat were holding to a double-digit lead.

LeBron leaving court. Right ankle, it looked like. Headed to locker room.

— Tim Reynolds (@ByTimReynolds) October 31, 2012

After his departure the Heat actually went on a 12-2 run to open up a 96-73 lead at the end of the third quarter.

James had 24 points in 26 minutes on 9-of-14 shooting, including two of three from three-point range. He's also pulled down 10 rebounds.

James has returned to the court and appears ready to test his ankle at the start of the final quarter.

LeBron back

— Rachel Nichols (@Rachel__Nichols) October 31, 2012

Bleacher Report will keep you updated on any changes in his status.