Andrew Luck and Brandon Weeden both desperately need wins this week in order to stay relevant this season.
The Colts, coming off of a 2-14 season last year, cleaned house over the off-season and are looking for their new talent to revive them back to their former glory from a few years ago.
The Browns, coming off of a 4-12 season last year, are looking to lose their reputation as one of the consistently bad teams of the last two decades.
Both teams are using a lot of young players this season, including quite a few rookies.
Here are the rookies to keep an eye on for Sunday.