While the No. 12 seeds are typically at-large teams, they do not stand much of a chance of winning it all. You can bank on a No. 12 seed upsetting a No. 5 seed just about every year, but the farthest one has ever gone was Missouri reaching the Elite Eight in 2002.
Long Beach State: 5,000-1 (Round of 32)
Long Beach State has had Cinderella written all over it since upsetting Pittsburgh in November. Playing teams like Pittsburgh, Xavier, North Carolina, Louisville, Kansas State and Kansas will pay off as the 49ers upset No. 5 New Mexico
Harvard: 10,000-1 (Round of 64)
Harvard has made its first NCAA tournament appearance since 1946, but the Crimson will not beat No. 5 Vanderbilt, which just beat Kentucky en route to winning the SEC tournament. The Commodores are hot, and Harvard cannot stop them.
VCU: 3,000-1 (Round of 32)
Shaka Smart's crew will be led by Bradford Burgess to an upset of No. 5 Wichita State. Not even Garrett Stutz will be able to beat VCU in the first round after the Rams' run to the Final Four last year.
South Florida: 10,000-1 (First Four)
South Florida doesn't have a single player averaging double-digit points per game, which is troubling to say that least. The team should not have made it into the tournament in my mind, and it stands next to no chance against California in the First Four.
California: 10,000-1 (Round of 64)
Speaking of Cal, the team will be able to beat South Florida, but it has struggled against good teams this year, and No. 5 Temple falls into that category for sure as the Owls even beat Duke this season.
Temple should be able to put together a good enough game to beat California, but Cal will get one win this year, over USF.