Brett Favre's unearthly streak of 297 consecutive regular season starts officially comes to an end tonight.
Favre appears on the official list of inactives for tonight's delayed Minnesota Vikings game in Detroit, where they will face the New York Giants.
This ends a streak that began in 1992 and followed Favre through a storied career with the Green Bay Packers, one year with the New York Jets and two seasons with the Vikings.
Counting the playoffs and a Super Bowl victory, Favre's total consecutive start total equals 321 games.
Favre was injured during the first drive last week, suffering a shoulder sprain against the Buffalo Bills when he was hit from behind by linebacker Arthur Moats.
Tavaris Jackson will start for the Vikings tonight and likely for the rest of the season. ESPN reports suggest Favre may go on injured reserve, marking the likely end of his career.
Joe Webb will serve as Jackson's backup quarterback.
Famed Indianapolis Colts quarterback Peyton Manning how holds the highest active regular season starting streak with 205 consecutive starts, already the second-highest in history for an NFL quarterback.
The Favre headline is not the only twist in tonight's game. Originally scheduled in the early slot for Sunday, the Vikings-Giants game was already delayed until tonight following a huge snowstorm in the Minnesota area.
After the Superdome roof collapsed under the weight of more than a foot of snow, the matchup was moved to Detroit's Ford Field, making a home game for the Vikings set in potentially hostile territory.