College Football Picks Against the Spread: Can Ohio State Cover and More

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College Football Picks Against the Spread: Can Ohio State Cover and More
Jamie Sabau/Getty Images
Terrelle Pryor

It's time to take a look at some of the spreads of the biggest college football games of Week 2. Week 1 was marked by the tradition of power schools beating up on the weak and infirm of the college football world. 

But in it's second week, the 2010 season brings us some juicy matchups, as well as some interesting lines heading into Friday. Whose spread is a little too big? Whose is just right? Let's take a look. 

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