The veteran allowed just one unearned run in four innings against the Los Angeles Angels on Tuesday night but was forced to leave in the fifth inning because of an injury. According to Max Wildstein of Scout.com, the pitcher was diagnosed with a strain in his left hamstring.
This comes after throwing eight scoreless innings in his previous start against the Boston Red Sox.
Injuries have become a problem for Sabathia in recent years after being a workhorse throughout much of his career.
The southpaw totaled at least 230 innings in each of his first three seasons with the Yankees, reaching at least 200 in seven straight seasons. He hasn't reached this milestone in any of the last three years.
His production has also fell dramatically. Sabathia finished 9-12 with a 3.91 ERA in 2016 in what was unquestionably his best season since 2012.
Coming into Tuesday, he had a 3.66 ERA to go with a 7-2 record in 12 starts.
While the Yankees rotation has stabilized in recent weeks, the latest issue could be devastating.
Meanwhile, the 36-year-old has his future to worry about in the final year of his contract. Even if he has performed well on the field, any missed time due to injury could create question marks when he hits the open market.