While many teams have already ensured their qualification to Brazil next year, there's a host of others that still have to contend with playoff fixtures to try to win their spots.
And while not all are officially confirmed, there's certainly some stellar matchups to watch out for.
Can New Zealand end Mexico's tumultuous summer over two legs? The All Whites will take a huge boost from Mexico's poor road form and the fact they'll be without Chicharito for the first leg.
Jordan might seem up against it when they take on the might of Uruguay, but given the geographical difference of the two nations, don't be surprised to see a very tight leg in Asia. Jordan have been relatively sound at home throughout qualifying and can trouble the South Americans.
African playoffs are already one leg through, where there's a real chance that some big-name teams in Egypt, Ethiopia, Cameroon and Algeria could all miss the World Cup.
And then there's Europe, where the top-draw matches could be numerous.
We could have Sweden trying to get through against the attacking strength of Croatia; we could have Ukraine trying to topple Romania's solidity in midfield; we could have Portugal taking on France, where the big-name players and world-class wingers would simply write the storyline themselves.
November is set to be a very busy month indeed.