It seemed to be a bit of a repeat of game one when ten seconds into the game Daniel Cleary took an interference penalty.
Fredrik Modin had a great opportunity however; red hot Chris Osgood continued to play solid and denied Modin of a goal.
Detroit came out strong and seemed to be the better team as Marian Hossa and Pavel Datsyuk made a great play with Steve Mason making a great save.
On a penalty to Jakub Vorachek for hooking, Brian Rafalski took advantage and scored to start the Red Wings off to a, 1-0, lead in the first period.
As the second period was underway both teams came out very strong as Osgood and Mason made great saves and denied chances.
On a bad giveaway by Detroit R.J Umberger was all alone but a great defensive play by Brad Stuart left him without a shot.
After another penalty call to Vermette Detroit went on another power play and it was Pavel Datsyuk who scored from a great pass from Hossa to lead, 2-0.
Henrik Zetterberg scored midway through the second period to give Detroit a 3-0 lead.
With the third period underway tempers flared as Jason Chimera took a boarding penalty on a dangerous hit to Nick Kronwall and Jiri Hudler added another power play goal for Detroit for a 4-0 lead and a win.
Detroit leads the series 2-0 and will play Tuesday night at 7 p.m. in Columbus.