Liverpool's European record (overall): Pld 298 Won 171 Drawn 64 Lost 63.
Liverpool's record in European Cup: Pld 167 Won 99 Drawn 35 Lost 33.
Pepe Reina will make his 100th appearance in UEFA club competition.
He will also become the first Liverpool goalkeeper and the sixth player overall to play 50 times for the club in the European Cup.
The next win will be Liverpool's 100th in the European Cup. Their first came in August 1964 when they won 5-0 in Reykjavik.
The Reds are playing in their fourth quarter-final in five years under Rafa Benitez.
Liverpool have met Chelsea in this competition in every season of Rafa's reign.
Steven Gerrard has scored in two quarter-final stages of the Champions League. If he scores in this tie he will equal Sami Hyypia's club record of three.
The Reds have already beaten Chelsea in both league fixtures this season for the first time since 1989-90.
This is Liverpool's 13th European Cup quarter final and they are aiming to reach the semifinal for the 10th time. Only CSKA Sofia (1982), Widzew Lodz (1983) and Bayer Leverkusen (2002) have eliminated the Reds at this stage.
The Reds are unbeaten in the last 32 games at Anfield in all competitions in the last 14 months.
Liverpool are meeting English opposition in a European tie for the ninth time. The Reds have won just four of the previous 16 games drawing seven times.
Steven Gerrard goes into the quarter finals as the joint leading scorer in the competition this season along with Bayern Munich's Miroslav Klose.
If Steven scores again during this campaign he will break the club record of seven European Cup goals in a season currently held by Roger Hunt (1964-65), Gerrard himself (2005-06), Peter Crouch (2006-07) and Dirk Kuyt last season.
Liverpool have won all five Champions League knockout ties under Rafa Benitez when the first leg has been played on a Wednesday.
The Reds have beaten Chelsea in knockout European football in odd years (2005 and 2007) with Chelsea prevailing in 2008.
Steven Gerrard has scored against every team he has faced in Europe this season from the group stage onwards.
He has scored 32 goals in Europe, the most by any British player for one English club. His next goal will take him past Alan Shearer whose 32 goals came with two clubs (30 for Newcastle and two for Blackburn). He is still some way behind Ruud Van Nistelrooy who scored 38 for Manchester United while Thierry Henry has hit the most for a British club – 42 for Arsenal.
Gerrard could break his own club record by scoring in a fifth successive home game in Europe.
Of the eight previous European meetings only Steven Gerrard and Jamie Carragher have appeared in them all for the Reds.
Steven Gerrard is two goals away from equalling his best ever tally in a season. That was set three seasons ago when he scored 23 times.
Yossi Benayoun's winner at Fulham last Saturday was the 10th occasion that the Reds had scored in injury time this season. They have found the net 26 times in the last 15 minutes.
The Reds have conceded only one goal in the last five games, and none from open play, since losing at Middlesbrough.
They are looking for a sixth successive victory in all competitions which will be their best run of the season.
A win tomorrow night will be their 50th over Chelsea at Anfield in this the 76th meeting on this ground in all competitions.
Chelsea's European record (overall): Pld 131 Won 70 Drawn 36 Lost 25.
Chelsea's record in European Cup: Pld 83 Won 42 Drawn 25 Lost 16.
This is Chelsea's 17th season in Europe and their seventh in the European Cup. They have reached the semi-final in this competition four times, all in the last five seasons.
They are aiming to become the first London club to win the European Cup.
In the first six meetings between the clubs in Europe only three goals were scored. Last season the two meetings produced seven.
All three previous knockout ties between the teams have been decided in favour of the team playing at home in the second leg.
Chelsea are looking for their first away win in Europe since they beat Rosenborg 4-0 in November 2007. Since then they drawn five and lost two.
This season in the group stage they drew at Cluj and Bordeaux but lost at Roma and held Juventus 2-2 in Turin in the last 16.
Ashley Cole last season became the first English player to appear in a European Cup final with two different English clubs.
Deco hopes to join Edgar Davids in winning the Champions League with three different clubs having already won the trophy with Porto in 2004 and Barcelona in 2006. He scored for the Spaniards against Liverpool in 2007 with the Reds coming from behind to win 2-1.
Petr Cech, Jose Bosingwa, John Terry, John Mikel Obi and Nicolas Anelka have featured in all eight games this season while Cech and Terry have not missed a minute.
Guus Hiddink won the European Cup as a coach with PSV Eindhoven in 1988. Only Ernst Happel (Feyenoord 1970, Hamburg 1983) and Ottmar Hitzfeld (Borussia Dortmund 1997, Bayern Munich 2001) have won it with different clubs.
Hiddink has managed in 40 Champions League games in his career, winning 18 and losing 13 while with PSV Eindhoven, Real Madrid and Chelsea.
Chelsea have lost both of their penalty shoot-outs in Europe - both to English clubs – Liverpool in 2007 and Manchester United in 2008.
Didier Drogba made his 50th Champions League appearance against Juventus in the first leg of the last round. He was sent off in last season's final.
The sides have met on 22 previous occasions in all competitions since the summer of 2004. Only two players, Jamie Carragher and Frank Lampard have played in them all.
Chelsea have played 10 games since Guus Hiddink was appointed on February 11, winning eight and losing only once – at Tottenham last month. They have kept six clean sheets while failing to score only once in that time.
The Londoners have never lost a quarter-final to Liverpool. They won at Anfield in an FA Cup tie in 1932 and beat the Reds at Stamford Bridge in the League Cup in 2007 – both by a 2-0 scoreline.
Claus Bo Larsen will take charge of this game. The Dane has referred Liverpool three times and Chelsea twice in the Champions League and neither side has ever managed to win.
He was the man in the middle when Chelsea lost at Fenerbahce at this stage last season. It will be the first time he has officiated at Anfield.
Current leading scorers: (Europe in brackets):
Liverpool: Gerrard 21 (7), Torres 11 (1), Kuyt 10 (2), Keane 7 (2), Benayoun 5 (1), Riera 5 (1), Alonso 3 (0), Babel 3 (1), Aurelio 2 (0), Dossena 2 (1), Hyypia 2 (0), Ngog 2 (1), Agger 1 (0), Arbeloa 1 (0), Carragher 1 (0), Lucas 1 (0), Plessis 1 (0), own goals 1 (0).
Chelsea: Anelka 21 (2), Lampard 16 (1), Kalou 8 (1), Drogba 7 (3), Malouda 5 (1), Ballack 3 (0), Belletti 3 (0), J. Cole 3 (1), Deco 3 (0), Terry 3 (2), Alex 2 (0), Bosingwa 2 (0), Essien 2 (1), Carvalho 1 (0), own goals 2 (0).