United sprinted out in front early on two goals in the game's first 12 minutes. Chelsea defender David Luiz gave United a massive present as a Robin van Persie shot ricocheted off the post and off Luiz's back for an own goal.
United wasted no time making the score 2-0 as van Persie gashed through Chelsea's defense, making the game's second goal look easy in the 12th minute.
Chelsea needed a goal before halftime to enter the match's final frame with some momentum, and they got just that on a 44th minute goal from Juan Mata. He curved a free kick right around goalkeeper David De Gea to put Chelsea on the board.
Mata's goal just before half powered The Blues to score early in the second half and tie the match up at two goals apiece, when a beautiful Oscar cross from the left side of the box found the head of Ramires for a fantastic finish.
Some controversial calls spurned Chelsea's momentum, as Branislav Ivanovic was sent off in the 63rd minute with a tackle of Ashley Young. Fernando Torres was also given his second yellow card just minutes later, after being called for diving in another call that put the Stamford Bridge crowd in peril.
Chelsea were forced to play the match's final 20 minutes with just nine men, and that cost them as Javier Hernandez scored quickly after entering the game as a substitute. The score from Chicharito put United up 3-2, and they never looked back.
The loss Sunday was Chelsea's first of the Premier League season, and Manchester United's improbable victory was their first at Stamford Bridge in the EPL in nearly a decade.
Juan Mata's brilliant free kick gave Chelsea some life late in the first half.
A series of stellar crosses resulted in a match-tying goal by Ramires for Chelsea as they begun their second-half surge.
Chelsea's home crowd was stunned with the sending off of Ivanovic, and it surely was a turning point in this tightly-contested match.
Chicharito's late goal proved to be the difference for Manchester United. Was he offside, though? You make the call.
Robin van Persie, Manchester United: A-
Manchester United would've been lost early without van Persie, who was a major component of the early own goal and who notched United's second score with a brilliant display of footwork in the box.
He made Chelsea's defenders look foolish all night, and that alone gives him a solid grade for Sunday's all-important match.
It was obvious who the most skilled attacking player on the pitch was.
Javier Hernandez, Manchester United: B+
Hernandez came on the pitch late in the match with one mission, and that was to take advantage of his squad's two-man advantage and notch the game-winning goal. He did just that.
After a near goal from van Persie that nestled on the goal line before being partially cleared by a Chelsea defender, the ball was crossed to Chicharito. He had no trouble finishing the game-winner from just about five yards out.
David Luiz, Chelsea: D+
Luiz is an integral part of Chelsea's defense, and with that comes a ton of pressure. He didn't live up to that pressure today.
He and Chelsea's defense were gashed by Manchester United throughout all of the first half, and a lack of presence of mind resulted in an own goal in the game's opening minutes. He aided in pushing the attack in the late minutes, but his team was already two men down and it was all but a formality.
Juan Mata, Chelsea: B+
Chelsea may have come away from this match with no points, but one of the shining moments on their side was the play of Juan Mata.
Mata was a force offensively throughout Chelsea's early second-half comeback, and his brilliant free-kick goal was just what his squad needed to mount the comeback.
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