This is also the last real chance for both Mayweather and Cotto to sell the fight to anyone who might be on the fence.
Surely, there's someone out there who might still have to think about ordering the show on pay-per-view.
We will have all the news and analysis from the weigh-in, and tell you what to expect from the MGM Grand Casino on Saturday night.
Will There Be A Pull-Apart At The Weigh-In?
Where: MGM Grand Casino in Las Vegas, NV
When: Friday, May 4 at 6:00 p.m. EST
Watch: HBO, SportsCenter
Betting Line: Floyd Mayweather (-700) according to Bovada
WBA (Super) Light Middleweight Championship: Miguel Cotto (c) vs. Floyd Mayweather
WBC Light Middleweight Championship: Saul Alvarez (c) vs. Shane Mosley
Light Welterweight Bout: Jessie Vargas vs. Steve Forbes
Super Welterweight Bout: Deandre Latimore vs. Carlos Quintana
Not yet available, will be updated as they are announced.
What Mayweather Must Do To Win
Use defense and speed to avoid heavy shots early to set up offense late.
Mayweather loves to bait opponents into making a mistake, then pounces on it because he's that quick and powerful. There's no one in the sport quite like him, which is why he has been so successful throughout his career.
As long as Mayweather isn't trying to match Cotto shot for shot in the early stages of the fight, he's going to be able to wear the champion down and then attack him in the later rounds.
What Cotto Must Do To Win
Attack early; keep enough stamina to keep up with Mayweather in the later rounds
Cotto can't give Mayweather an opening early, or else he's going to be in for a long fight. He has to find that one opening in the first few rounds to stun Mayweather.
If he is able to do that, Cotto will have a great chance to pull off the upset.
Stamina is going to play a big role in the outcome of this fight.
Mayweather is the best conditioned boxer in the world, so Cotto has to plan for a long, physical fight that moves fast for 36 minutes.