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The 6-5 Tennessee Titans, whose playoff hopes have been renewed with Houston's loss of its top two quarterbacks, visit the 5-6 Buffalo Bills, who would likely have to win out to have a shot at the playoffs.
Titans quarterback Matt Hasselbeck has had a very good year in his first season in Tennessee, and he's carried this team in the wake of running back Chris Johnson's struggles.
Johnson may have finally found his groove, however, tearing up the Tampa Bay Buccaneers for 190 yards last week. Tennessee's depleted receiving corps is led by Nate Washington, Damian Williams and tight end Jared Cook.
The defense has been very good in terms of points allowed (seventh in the NFL), but an already-iffy rush defense will take a hit with the absence of starting middle linebacker Barrett Ruud.
The Bills are led by quarterback Ryan Fitzpatrick, who has had a pretty good year, but running back Fred Jackson was put on the IR earlier this season following awful losses to Dallas and Miami.
Receiver Stevie Johnson, who is now an infamous figure for his touchdown dance against the Jets, still showed his skill by catching eight passes and a touchdown on cornerback Darrelle Revis. Johnson will likely draw coverage from Titans cornerback Cortland Finnegan.
Defensively, the Bills haven't been good all year, and they seem to be regressing. They rank 28th in the NFL in scoring defense.
The Titans' playoff hopes are still alive, and they'll keep them alive this week by beating an ailing Buffalo Bills squad.
Titans 27, Bills 17