Timothy T. Ludwig-USA TODAY Sports
This may come as a surprise to some, but the Buffalo Bills currently have the eighth-best defense in the NFL and fifth-best passing defense in terms of yards. They have shown improvement in a number of different areas over the season and are playing some of their best football right now.
In Week 1, Buffalo gave up 288 passing yards and two touchdowns to Tom Brady in the 23-21 loss. This is on par with Brady's career numbers against Buffalo: He's averaging 247.6 yards and 2.3 touchdowns per game in 23 career starts.
This is a different defense, however, than the one the Patriots faced in Week 1. The Bills were without Jairus Byrd and Stephon Gilmore in their secondary, and both have played a major role in the defense's improvement.
The key to stopping Tom Brady is to get pressure on him in the pocket, and this is an area the Bills defense has excelled in. They are currently first in the NFL in sacks with 56 and have three players (Mario Williams, Kyle Williams, Jerry Hughes) who have double-digit sacks this year.
If Buffalo is able to effectively rush the quarterback, Brady will not have a fun time throwing the ball.