These clubs will be forever linked by their battles in the 1980s.
Losing three AFC championship matches to the Broncos during that decade and of course "The Drive," still make long-time Browns fans sick.
Although this Week 16 meeting does not quite add up to those epic encounters of the past, the outcome is still important for both teams.
Denver is gunning for home-field advantage, while Cleveland players try to impress management for next season.
There are 10 keys to this game for Cleveland that will help them tame a Denver squad that has won nine straight.