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The Chiefs' best weapon is probably running back Jamaal Charles, who seems to be fully recovered from a nasty injury last season. Charles doesn't get the ball as much as he should given the team's passing woes, but when he does he's dangerous.
The Steelers are the league's top team against the pass, but they have been a lot more pliable against the run than in previous years. Part of that is some age up the middle of the defense. Another factor is the injury to Troy Polamalu, who is usually good at sealing some extra running lanes.
The Steelers need to keep the Chiefs from getting their ground game on track this week. They have to keep Charles and his mates bottled up. That will allow them to keep time of possession heavily in their favor and also force the Chiefs to pass, which we've already covered as being deadly to their chances of beating Pittsburgh.
The best way to do this is to insert Steve McLendon often on early downs and allow his superior athleticism and quickness to cover the gaps. The Chiefs don't have a great line, so shutting them down shouldn't be difficult if the effort is there.