They are also looking to get over the loss from the last time they were in Lucas Oil Stadium.
The New England Patriots were defeated in 2009 by the Indianapolis Colts 35-34 at the Colts home field.
The infamous failed 4th-and-2 attempt by Bill Belichick was the main story after the game.
Belichick had no faith in his defense with two minutes remaining and clinging to a six-point lead. The play resulted in a controversial spot of the ball leaving the Patriots' possession just inches short of a game-winning first down.
The turnover led to a three play, 29-yard drive capped by a one-yard touchdown by Peyton Manning. The extra point gave the Colts the one-point win.
Belichick tried to flex his muscles in that game and was not able to execute. He will look for better results in this year's Super Bowl.
However, his quarterback might have a bit of trouble getting comfortable in the confines of Lucas Oil Stadium.
When Tom Brady suits up for the game on February 5, he will be dressing at his arch rivals locker.
Since the AFC is hosting the Super Bowl, the AFC Champions dress in the home team's locker room.
Meaning Brady will be dressing at Peyton Manning's locker. An odd situation and a bit ironic.
Tom Brady's first career start was a win against the Colts in 2001. He is looking to win his fourth championship in the Colts' home stadium in Super Bowl XLVI. Brady will be looking to tie Terry Bradshaw and Joe Montana with four Super Bowl victories.
Manning and Brady will go down as two of the greatest quarterbacks that have ever played. Their head-to-head meetings have been classic. Every year when the schedules are released, it is one of the first games that fans find.
Fans will have to wait another season for the Peyton and Brady rivalry to continue. This season, it is an Eli Manning and Brady rivalry that takes center stage.
Six months ago, no one would have thought Tom Brady would be using Peyton Manning's locker while Peyton gets ready to move his things out of Indy.