Dan Herron vs. Bengals Run Defense
The starters likely won't get much work in on Thursday, giving players like "Boom" Herron a chance to get some significant reps against the Bengals.
In the first three preseason games, Herron has already run for 104 yards on just 18 carries while also putting up 53 yards and a touchdown on 10 receptions. He's arguably been the biggest surprise for the Colts this preseason, but the Bengals have a tough front seven, including some intimidating backups like Margus Hunt and Robert Geathers.
The Bengals allowed just 96.5 rushing yards per game last season, so this will be a great opportunity for Herron to prove himself against a tough run defense.
Colts Run Defense vs. Bengals Running Backs
They're not the best running team in the NFL, but the Bengals have a number of options in the backfield that will keep the Colts defense on its toes.
Along with Giovani Bernard, who exploded onto the scene during his rookie season, the Bengals also have BenJarvus Green-Ellis and promising rookie Jeremy Hill out of LSU. The Colts have given up 114.7 rushing yards per game this preseason but have allowed just 3.4 yards per carry, which is actually tied for the seventh-best mark in the league.
The Colts have already gone against some solid backs so far in the first three games, but none of the other teams had as much backfield depth as Cincinnati.
Zach Kerr vs. Bengals Offensive Line
As mentioned earlier, Kerr was worked his tail off this preseason and has likely secured a roster spot heading into the regular season, but this is still a good test to see what he can do in the final game before Week 1.
On the inside, the Bengals don't have a ton of depth, which means that Kerr could have the chance to go against some weaker players on the inside of the offensive line. At 6'2'' and 335 pounds, he's been a force this preseason coming out of Delaware, even getting a sack last week against the Saints.
If Kerr continues to play well on Thursday, there's a chance he could be the go-to backup behind Arthur Jones at defensive tackle.
Colts' X-Factor of the Week: Henoc Muamba
Grigson hasn't been afraid to cast an extremely wide net, and that includes taking players from the CFL, like Jerrell Freeman, who has been a huge piece of the defense the past couple of seasons.
Now, the Colts might have found another gem out of Canada.
Henoc Muamba, who signed with the Colts back in February, has looked terrific this preseason, racking up 16 tackles, a sack and two forced fumbles. He's done a good job filling in when needed at inside linebacker and could even end up moving past Kelvin Sheppard on the depth chart with how well he's played.
Through the first three preseason games, it's pretty safe to say that Muamba will be on the final roster, but look for him to make even more big plays on Thursday.