Frank Augstein/Associated Press
All systems go: Thiago Alcantara should play.
According to Barcelona-based Sport, a Spanish language publication, Cesc Fabregas is a doubt for the game because of an injury he sustained against Almeria on Sunday night.
The creative midfielder was substituted after 78 minutes for Andres Iniesta and is undertaking medical tests for a groin injury.
Spain's team doctors are likely to decide it's not worth risking him in a friendly.
The Catalan giants will probably be hoping that Xavi and Iniesta aren't used too much either as they chase Real Madrid at the top of La Liga.
Del Bosque spoke about Bayern's Thiago Alcantara, and he hinted that he was going to start.
As per AS, Spain's boss said: "He’s playing very well for Bayern Munich, one of the best teams in Europe, and he’s a starter."
Sergio Busquets is likely to anchor the midfield, and it's tricky to pick between Koke and Xabi Alonso for the other position.
Perhaps Del Bosque will be swayed by the game's location to pick Atleti's youngster Koke in his own stadium, but Real Madrid's Alonso offers the balance the team needs and the coach will want to see how he and Thiago play together as well.