Denver bettors hope the results on Monday Night Football are different than recent results when their team is in this situation, as a road underdog of one point.
The Broncos face another tough task when they take on the AFC West-leading San Diego Chargers at QualComm Stadium (8:30 pm ET, ESPN). They also look to buck a handful of negative trends.
"They are 2-6 ATS in their past eight Monday Nighters and 1-5 ATS in their past six games as an underdog," said Jack Randall of OddsShark.com. "They are 3-8-1 ATS in 12 games against San Diego and 1-8 ATS in nine October games."
And don't forget the scores prediction computer picked a 30-28 result for the home team in an article posted here last week.
Can the Broncos get their act together and forge a tie for first place in the West? Or will the Chargers take charge with another divisional victory before both teams hit their bye week? And is the OVER the best bet of the night, given the one-sided trend in San Diego pre-bye-week games (12 OVERs and 1 UNDER past 13 seasons in this situation)?
Manning and Denver began their partnership with a 31-19 season-opening victory over the Steelers. But then Eli's brother had that terrible first quarter that led to a 27-21 loss in Atlanta.
After that the Broncos didn't score a touchdown until down by 20 points in the fourth quarter in a 31-25 loss to Houston.
Denver then picked up a 37-6 victory over Oakland, but last week fell behind the Patriots in New England 31-7 before getting a couple of late scores to make the final halfway respectable at 31-21
San Diego, meanwhile, opened its season with wins over the Raiders and Titans and an ugly loss to the Falcons. The Chargers then got a divisional road victory, beating the Chiefs in KC 37-20, before giving up a 10-point lead last week and losing at New Orleans 31-24.
So the Broncos, at 2-3, trail 3-2 San Diego by a game going into Monday night. A Denver win forges a tie atop the AFC West, while a Broncos loss gives the Chargers a solid early-season lead and a 3-0 divisional record.
As for the betting on this game most online sportsbooks opened Denver as a three-point underdog. But as of Monday morning the Broncos were only getting one point at most NFL betting shops.
Also, while the OVER/UNDER on Monday's game started off at upwards of 51, its since been bet down to as low as 47 at some sportsbooks.
These two original AFL franchises have met 104 times; Denver leads the all-time series 55-48, with one tie, but San Diego has won nine of the last 12. Last year these rivals split their two games, the Broncos winning at Qualcomm and the Chargers winning at Mile High.
Both those games involved some guy named Tebow playing QB for Denver, and neither involved Manning.
Monday Night Football Pick: Chargers -1, OVER 47 (courtesy of PickShark.com)
All odds, stats and trends mentioned courtesy of OddShark.com Mike Pickett is a Contributor to Bleacher Report. Unless otherwise noted, all quotes were obtained firsthand.