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Honestly, it shouldn't be hard at all for FC Barcelona to triumph over Spartak Moscow. Spartak are now being managed by the very talented Unai Emery, but their squad is still rather limited technically, and has gotten off to a rather subpar start in the league.
Emmanuel Emenike, Welliton, Ari and Artem Dzyuba have all yet to register a single goal in seven games, and the team has yet to settle into any sort of rhythm.
There are a few things that Tito Vilanova should keep in mind though, to ensure victory for his team. Though Spartak's centre-forwards have struggled in front of goal, they've been fairly good at laying the ball off to the team's midfield to do the scoring.
Dmitri Kombarov in particular has made a strong start to the season because of this. As such, Barcelona's centre-backs should take particular care to shut down the team's centre-forward and the man behind him, whoever they may be.
All of Spartak's forwards are fairly pacey as well, so this will be something for Barca's centre-backs to watch for as well.
To close though, with Barcelona playing at the Camp Nou, this match should be a stroll in the park. Emery hasn't yet been able to take all the various pieces available to him at Spartak and mold them into a single identity.
I expect Barca to impose their style, dominate possession and easily finish at least two or three of their scoring chances. Anything less than a two-goal margin victory here would be a big surprise for me.