7:15 p.m. PT, ESPN
The Raiders split the series in 2011, winning by a touchdown in Week 10 in San Diego and losing by 12 with the season on the line at home in the finale.
In the late game on a weeknight, the Raiders get an opportunity to make a statement that they should be in the playoff conversation.
Denarius Moore was a problem for the San Diego secondary in 2011 because Quentin Jammer couldn't handle him. Moore racked up 224 yards through the air and two touchdowns versus the Chargers last season.
In the first matchup, Darrius Heyward-Bey was held without a catch, but in the finale Antoine Cason had trouble with Darrius Heyward-Bey as he exploded for 130 yards and a touchdown.
Despite good numbers through the air, the Raiders win against San Diego was largely due to the Raiders ability to pressure Philip Rivers and the dominate running game. The Raiders were able to do neither against the Chargers in the finale and lost.
The Raiders were very close to signing Jared Gaither to a contract last offseason. It was to the point that Gaither had to do no more than pass a physical. He failed that physical and signed with the Kansas City Chiefs.
After 10 games as a backup with the Chiefs, he was released and signed with the Chargers. Gaither salvaged the Chargers season and started the final five games at left tackle.
Matt Shaughnessy can't seem to stay healthy, but the Raiders will handle him with kid gloves during training camp in hopes he will be ready to go for the season opener and beyond.
Pressuring Rivers is vitally important and it all starts on the blind side. Shaughnessy is capable of dominating a game, but he'll need to beat up on a good left tackle in Gaither to do it.
Largely due to Darren McFadden's injury history, he has faced the Chargers just one time as a starter, a 28-13 Raiders victory in Week 13 of 2010.
McFadden is one of the most explosive offensive weapons in the league and the Raiders' best offensive player. The emergence of the passing game in Oakland will only help McFadden find holes.
The Chargers have a veteran front seven that is smart, but lacks the perimeter speed to keep up with the outside zone they will see from the Raiders.
PREDICTION: Chargers 20, Raiders 27