Tony Romo has been knocked out of the game with a hand injury, according to ESPN's John Clayton.

The Cowboys are in must-win mode and can't afford to eat a loss against the Eagles this week. Romo put his toughness on display by playing with broken ribs and a punctured lung to bring the Cowboys back against the 49ers.

Update: Saturday, December 24th at 5:15 p.m. EST

Romo is done for the day, according to ESPN's John Clayton.

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Initial Update:

The Cowboys need to see those heroics on display right now if they are going to have any shot at cracking the postseason.

Backup Steven McGee isn't going to be able to bring them a much-needed victory this week and he's got no shot at taking down Eli Manning and the Giants if Romo's injury knocks him out of next week's game.

ESPN's Tim McMahon says there is no protection on Romo's injured hand yet, but there is no word yet on his status.

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National Football Post's Andrew Brandt points to the swelling in Romo's hand, likening it to a catcher's mitt.

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Playing through pain is one thing. The swelling in his hand may force the Cowboys to protect Romo from himself.

His hand coming into contact with Jason Babin's helmet could essentially seal their fate as a non-playoff team.

The Cowboys are clinging to their playoff lives and this is yet another unlucky turn of events for the underachieving Cowboys.