Brees threw for four touchdowns against zero interceptions and raised questions as to his MVP status, while on the other hand his counterpart completed 20-straight passes at one point during the game.
This week's quarterback matchups will prove to play no different, and with fantasy playoffs right around the corner, you'll be lucky to have one of these six studs.
Here are six gunslingers who I think are good for at least 300 yards and a couple touchdowns in Week 13.
Eli Manning couldn't quite lead his team to a victory on Monday night, but luckily for his fantasy owners that doesn't hinder his scoring output.
Manning surpassed 400 yards passing against the Saints defense, and while I don't foresee him reaching the 400-yard plateau again, I am convinced he'll have a top 5 week numbers-wise.
The Giants are desperate for a win. Their Week 13 task will be daunting seeing as they host the undefeated Green Bay Packers.
The Packers defense has their pros and cons when it comes to the passing defense.
On one hand they force a lot of turnovers, but on the other they give up the second most yards per game average and a total of 19 passing touchdowns on the year.
Eli has looked as good as ever this season, and with the Giants desperate for a victory to stay in the division race, I expect them to ride their leader to the finish line.
The consensus MVP choice through two-thirds of the season has been nothing short of incredible on every front this season.
The last time we saw Rodgers and the Packers, they played side dish to our delectable Thanksgiving dinners and they were as good as advertised.
This week the Packers face off against the New York Giants who were just torched by Drew Brees to the tune of 360 yards and four touchdowns.
Rodgers won't have trouble with the Giants because of his mobility and decision-making, and those skills will allow him to put up his usual monster numbers.
Tom Brady put on an absolute clinic against the Philadelphia Eagles when he threw for 361 yards and three touchdowns.
This week he lines up opposite the Indianapolis Colts.
I feel that I shouldn't need to explain any further.
Matthew Stafford has gone through a rough patch the past three weeks in which he's tossed nine of his 13 interceptions on the season.
This week against the Saints, I expect Stafford to get out of his funk.
The Lions need to get back to sticking with their guns and getting the ball to Calvin Johnson early and often. If they can do that—like I expect them to—Stafford will benefit greatly.
While we may see one or two more interceptions from Stafford, you have to take the good with the bad. I feel like he's ready for another breakthrough game that includes 300 yards and a couple touchdowns.
Eh Tony, what are ya doin' over there on the sidelines?
Tony Romo has played fabulously in the Cowboys four-game win streak by throwing 10 touchdowns against only two interceptions.
The Arizona Cardinals give up 250 yards per game through the air, including 300 yard games to fellow NFC East quarterbacks Rex Grossman and Eli Manning.
Romo really has created a connection with his wide receivers, and he himself has benefited from having DeMarco Murray in the run game.
Look for Romo to continue his tear this weekend against the Cardinals.
Let's be honest, Drew Brees is the man.
The Saints quarterback is on pace to break every single passing record this season, and his showcase on Monday Night Football put his name right at the top of the MVP race along with Rodgers and Brady.
This week Brees lines up opposite the Detroit Lions defense who is badly banged up in the secondary and will be playing with out Ndamukong Suh.
Brees has so many options at his disposal and is so well at getting them all involved.
I expect another field day for the league's leading passer again this weekend, registering another three touchdowns.