The 31-year-old, who returned to Manchester for the first time since his move from City's neighbours Manchester United this summer, put a low shot underneath goalkeeper Ederson in the 35th minute.
Rooney was on hand to turn the ball in after a smart pull-back from 20-year-old forward Dominic Calvert-Lewin. It marked the England international's second league goal in as many matches since his return to boyhood club Everton.
Rooney's landmark strike also makes him only the second forward in Premier League history to reach the 200-mark for goals, per Squawka Football:
BT Sport and BBC Match of the Day presenter and former Everton striker Gary Lineker applauded Rooney's enduring class:
Shearer also recorded a special message for the man of the moment, saying he had been lonely in the 200 club, via the Premier League's official Twitter account:
Creative centre-forward Rooney has always been a natural talent, one who announced himself with his first league goal, a spectacular strike to help the Toffees beat Arsenal back in 2002.
Almost 15 years on, he's proving he still has a lot left to offer at the top level.