Sunday’s game will be the 26th regular-season meeting between the two with the Bills having won 10 of their previous 11 matchups.
The big storyline for the game is that Thaddeus Lewis is set to start at quarterback for Buffalo while E.J. Manuel recovers from injury.
Despite that, the Bengals will be weary of the Bills after being upset by the Cleveland Browns in Week 4. Doug Marrone's side has already toppled the Baltimore Ravens and will look to add Cincinnati to that list.
So, let's begin our preview of Sunday's game with six bold predictions for Week 6.