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Kickoff Time and Network: 4:25 p.m. ET, FOX
In 2012, the Arizona Cardinals brought in a four-game winning streak into the Edward Jones Dome. They had been piling up takeaways left and right, while doing just enough offensively. Fans and media members alike knew no team could continue to win games that way.
St. Louis decided they didn't want to become the next team to fall inside of this trap. So they went out and harassed quarterback Kevin Kolb to the tune of eight quarterback sacks. It's hard to imagine that happening again, but the Rams did lead the NFL in sacks last year, so Arizona's offensive line needs to prepare accordingly.
Protecting Carson Palmer against the daunting pass rush should be the biggest priority. Next, it should be making sure they win the field position battle. If those two things can't be done, it will be another long day in St. Louis.
Look for the Rams to narrowly escape thanks in large part to Greg Zuerlein's monster leg.
Prediction: Rams 21, Cardinals 20