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Rarely does a team miss on an entire draft class, but Pittsburgh managed to do so in 2008.
Here's a look at that class for Pittsburgh:
1st: Rashard Mendenhall, RB
2nd: Limas Sweed, WR
3rd: Bruce Davis, DE/OLB
4th: Tony Hills, OL
5th: Dennis Dixon, QB
6th: Mike Humpal, OLB
6th: Ryan Mundy, S
Only Mundy, Hill, Dixon and Mendenhall are still on NFL rosters and only Mendenhall had more than cursory success in Pittsburgh. Sweed was another second-round mistake that became injury-prone and error-prone. Hills never became more than a fringe backup.
The conversion of Davis to linebacker didn't work out, and he failed to contribute on future rosters. Humpal didn't make the team and never caught on anywhere.
Mendenhall had a couple of good seasons, but his big mouth got him in trouble with fans and his lackadaisical play in 2011 got him a ticket out of town. Mendenhall never truly took hold of the starting job either.
Dixon proved to be a decent backup, but never developed into more than a third-string player. Mundy became a solid backup, but his inability to hit legally or cover consistently hindered his development.