Brendan Rodgers will have had a full week working with his team. With no midweek clash to play, Liverpool should have had ample time to ensure that they are physically, tactically and mentally prepared to take the three points.
The manager will have a few decisions to make regarding his starting lineup, with Joe Allen and Raheem Sterling suffering from fatigue recently, while Nuri Sahin and Jose Enrique may be fit to return to the team.
It is in the full-back areas, though, where Liverpool will perhaps face the biggest challenges at both ends of the pitch.
Here's why Liverpool's right-backs and left-backs are key to victory in the upcoming game.
You can catch live text commentary of the Liverpool vs. Fulham match here on Bleacher Report. Kickoff is at 17:30 (UK) / 12:30 (ET) on Saturday, Dec. 22.