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The Thursday Night Football game between the Bengals and the Eagles could provide an early upset in Week 15, but the big upsets will start on Sunday.
The Seattle Seahawks are one playoff team that is on upset alert.
They are off a dominating win against the Cardinals and will not be prepared for this game against Buffalo.
The Seahawks will have one eye on the matchup with the Week 16 Sunday Night Football game against the San Francisco 49ers. With the 49ers playing the Patriots in Week 15, the Seahawks could get into a position to take over the division.
That is if they don't take the Bills lightly.
The Birds will be distracted as they travel across the country to take on Buffalo in, of all places, the Rodgers Center in Toronto Canada.
The Seahawks are 15-33-3 against the spread (ATS) in their last 51 games following a win of more than 14 points and will be upended by a scrappy Buffalo team.
Think that is an improbable upset?
This same philosophy led to a perfect 3-0 ATS record in the Week 14 picks, which include two outright upsets!
The Bills shock the Seahawks with a big win in Week 15.
NFL Pick Against the Spread: Buffalo +5.5
Prediction: Buffalo 17 Seattle 16