The win gives Denver a three-game lead over San Diego, and gave quarterback Peyton Manning 148 career wins, to tie former Bronco John Elway.
Manning had a solid if unspectacular game going 25/42 for 270 yards throwing three touchdowns and one interception.
The Broncos may not have played their best game but it was good enough to beat the struggling Chargers who have now lost five of their last six games.
So, which Broncos stepped up and helped Denver clinch this win?
And which ones didn't have their premium game?
Here are the Broncos' biggest winners and losers from Sunday's victory.