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The Jets, who are coming off a close loss to the unbeaten Houston Texans, will host the Colts, who are coming off one of the most emotional wins on the NFL season.
The latest NFL odds from BangTheBook.com have the Jets listed as a three-point favorite.
The Colts had a come-from-behind win over the Packers last week in a game that was dedicated to head coach Chuck Pagano, who is battling leukemia. It will be difficult for this young team to follow that inspirational win with a similar effort against the Jets.
Colts wide receiver Reggie Wayne is playing like a superstar again, but this week the Jets will make sure that Antonio Cromartie will cover him. Cromartie shut down Andre Johnson a week ago.
The Colts lost Donald Brown to an injury and will use rookie Vick Ballard out of the backfield on Sunday.
All signs point to the Jets, who qualify as one of BookieBlitz.com's top 10 trends of the week. They are 12-4-1 ATS in their last 17 games when playing on Sunday following a Monday night game.
The Colts are 0-12 ATS when playing a team with a losing record, and they will get run over by a desperate Jets teams looking for a win.
Best Bet: Jets -3