Both times occurred last season, which probably didn't bear mentioning since the second of those matchups was the NFC Championship game, where the 49ers Williamsed, I mean fumbled, away their opportunity to get to the Super Bowl and wound up losing, 20-17.
Anyway, you better believe the 49ers have had this game circled on their calendar for a long time, while the Giants were circling dates for parades, celebrations and talk show appearances.
Whether the 49ers claim a tiny bit of revenge or not, this game will be one of the highlights of Week 6.
Where: Candlestick Park in San Francisco, California
When: Sunday, October 14 at 4:25 p.m. ET
Live Stream: NFL Sunday Ticket
Listen: NFL Audio Pass
Betting Line: 49ers -6 (according to Football Locks on Oct. 10)
At the time of publication, the official injury report was not available.
Check out NFL.com for the report, as it should become available sometime Wednesday afternoon, and it will update as the week goes on.
The Giants running game is vastly outperforming expectations this year. Both Ahmad Bradshaw and Andre Brown have been pulling in solid fantasy points.
Well, Brown sustained a concussion, as the New York Daily News' Ralph Vacchiano reports, last week which leaves his playing status up in the air.
Fantasy owners shouldn't even bother with following his progress because he would have little value in this game. The 49ers can play some rush defense.
Bradshaw is still worth a start. He figures to get a solid amount of touches, and he is coming in off a 200-yard effort.
Go ahead and play anyone else you have in this matchup that would be a normal candidate to start, but don't look to this matchup for sleepers. With two quality teams like this going back and forth, both coaches are going to rely heavily on their proven commodities.
Giants Player To Watch: Eli Manning, QB
Eli Manning has been fantastic this season. He has had to deal with some serious injury issues with his offensive teammates, and he hasn't missed a beat.
In fact, his 96 quarterback rating and 65 percent completion percentage are the best of his career for a season.
This is an excellent quarterback in his prime. Enjoy.
49ers Player To Watch: Kyle Williams, WR
There is not going to be a player on the field trying harder to make a positive impact in this game than Kyle Williams after his disastrous performance in the championship game last year.
Williams has been lightly used on offense, but he does have four catches and three runs, which shows the 49ers will get creative while finding ways to get him the ball, and I got to believe they will give him a few chances to make a big play here.
Williams will also get a chance to make an impact with his returning ability.
Key Matchup: 49ers Rush Defense vs. Giants Rush Offense
As we mentioned above, the Giants have had solid success running the ball this year. They are 12th in rushing yards per game and sixth in yards per rush.
This offense is still geared around Eli Manning and the pass, but if the Giants are consistently churning out positive yards on the ground, this offense is unstoppable.
The 49ers have allowed the sixth-fewest yards per carry this year. This matchup will not only be key, it will be intense.
Prediction: 49ers 27, Giants 23
The 49ers are on fire right now. They've won their last two games by a combined score of 79-3, and they aren't going to leave anything in the tank as they try to erase the bad memories of their bitter playoff defeat a season ago.