Rick Stewart/Getty Images
Head back to the sidelines Scott.
Against the 49ers, the Buffalo Bills need to keep Frank Gore under 75 yards. After last week's game, this sounds easier said than done, but I think it's more likely than people believe.
Against the Bills, Brandon Bolden and Stevan Ridley rushed for 243 yards, but this is deceiving. For the first time this season, the Bills primarily featured a nickel defense.
The Bills kept Kelvin Sheppard and Arthur Moats, both strong in the run game, off the field for the majority of the game in favor of linebacker Bryan Scott and cornerback Justin Rogers.
The Bills felt that Scott was a better fit last week due to his past as a safety. While his coverage abilities are better than that of Sheppard or Moats, the Patriots took advantage of the Bills' undersized defense.
Against the 49ers, the Bills will be back to their traditional 4-3 look and Moats and Sheppard will help keep Gore in check.
If the Bills can keep Gore under 75 yards, there is a great chance that the 49ers will not have as much success moving the ball.
Final Prediction: Bills 16 - 49ers 13.