San Francisco 49ers vs Detroit Lions: Keys to the Game for 49ers and Prediction

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San Francisco 49ers vs Detroit Lions: Keys to the Game for 49ers and Prediction
Leon Halip/Getty Images

The last time the San Francisco 49ers and Detroit Lions met, Alex Smith had an awful game. Clearly bothered by the athletic defensive line of the Lions, Smith averaged just 3.9 yards per pass attempt and had two turnovers.

Fortunately for Smith, the running game, defense and special teams were all dominant in San Francisco's 25-19 win at Ford Field in October of last season.

After the Jim Harbaugh-Jim Schwartz postgame shenanigans, you have to believe that the Lions circled this game on their schedule. 

Will a fired-up Lions squad get revenge against Harbaugh's 49ers? Read on for the keys to the game and a prediction.

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